Lyme PCR-22-Plus™ Panel

This panel was specifically designed to detect the presence of the major bacteria, protozoa, and fungi associated with Lyme disease, tick or vector-borne infections, and other diseases. These tests use patented PCR primers. To vastly improve accuracy and sensitivity of the test, DNA sequencing is also used with the PCR information and processed by patented software to more clearly identify any organism. The system will not report organisms not within the Genus on the indicated list. For broader coverage please use full Bacterial or Fungal/Protozoal sequencing for much greater depth of coverage.

Lyme Serology/Antibody Testing

The Immunoblot for strain B31 of Lyme disease (Borrelia burgdorferi) is used to test for Lyme Disease. Basically, the test screens for several antibodies that your body makes when exposed to Lyme disease. The Immunoblot is like the standard Western Blot. Blood is required for the assay. As per guidelines there must be at least 5 bands positive for IgG or two bands positive for IgM to consider a positive test. This test requires a fresh blood sample. This assay is FDA approved.

This test detects antibodies to various proteins to the Lyme spirochete – Borrelia burgdorferi. Borrelia proteins (also known as antigens) are attached to a thin strip of material (blot) and the patient’s serum containing antibodies are allowed to bind to the proteins. We test for both IgG and IgM antibodies and follow the Center for Disease control criteria for Lyme disease. A positive test is indicated with two or more IgM bands or 5 or more IgG protein bands. It has been reported that patients with Lyme disease produce antibodies of the IgM class during the first weeks after onset of EM (rash) but produce IgG antibodies more slowly. Strips that have 5 (or more) out of 10 significant bands for IgG and 2 out of 3 significant bands for IgM are considered positive for antibodies to B. burgdorferi. Individuals being treated with antibiotics may not develop titers or will develop low antibody levels. It is suggested that patients be off antibiotics for two weeks prior to testing; however, this is subject to clinical necessity.

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Lyme PCR-22-Plus™

*If other pathogenic organisms within the Genus are detected they may be reported. Each Genus/and or species has been validated with ATCC or validated source samples.